Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia
Identifieur interne : 000592 ( Main/Corpus ); précédent : 000591; suivant : 000593Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia
Auteurs : Liana G. Apostolova ; Mona Beyer ; Amity E. Green ; Kristy S. Hwang ; Jonathan H. Morra ; Yi-Yu Chou ; Christina Avedissian ; Dag Aarsland ; Carmen C. Janvin ; Jan P. Larsen ; Jeffrey L. Cummings ; Paul M. ThompsonSource :
- Movement Disorders [ 0885-3185 ] ; 2010-04-30.
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Abstract
Parkinson's disease (PD) has been associated with mild cognitive impairment (PDMCI) and with dementia (PDD). Using radial distance mapping, we studied the 3D structural and volumetric differences between the hippocampi, caudates, and lateral ventricles in 20 cognitively normal elderly (NC), 12 cognitively normal PD (PDND), 8 PDMCI, and 15 PDD subjects and examined the associations between these structures and Unified Parkinson's Disease Rating Scale (UPDRS) Part III:motor subscale and Mini‐Mental State Examination (MMSE) performance. There were no hippocampal differences between the groups. 3D caudate statistical maps demonstrated significant left medial and lateral and right medial atrophy in the PDD vs. NC, and right medial and lateral caudate atrophy in PDD vs. PDND. PDMCI showed trend‐level significant left lateral caudate atrophy vs. NC. Both left and right ventricles were significantly larger in PDD relative to the NC and PDND with posterior (body/occipital horn) predominance. The magnitude of regionally significant between‐group differences in radial distance ranged between 20–30% for caudate and 5–20% for ventricles. UPDRS Part III:motor subscale score correlated with ventricular enlargement. MMSE showed significant correlation with expansion of the posterior lateral ventricles and trend‐level significant correlation with caudate head atrophy. Cognitive decline in PD is associated with anterior caudate atrophy and ventricular enlargement. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.22799
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Apostolova</name><affiliation><mods:affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Beyer, Mona" sort="Beyer, Mona" uniqKey="Beyer M" first="Mona" last="Beyer">Mona Beyer</name><affiliation><mods:affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Green, Amity E" sort="Green, Amity E" uniqKey="Green A" first="Amity E." last="Green">Amity E. Green</name><affiliation><mods:affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Hwang, Kristy S" sort="Hwang, Kristy S" uniqKey="Hwang K" first="Kristy S." last="Hwang">Kristy S. Hwang</name><affiliation><mods:affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Morra, Jonathan H" sort="Morra, Jonathan H" uniqKey="Morra J" first="Jonathan H." last="Morra">Jonathan H. Morra</name><affiliation><mods:affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Chou, Yi U" sort="Chou, Yi U" uniqKey="Chou Y" first="Yi-Yu" last="Chou">Yi-Yu Chou</name><affiliation><mods:affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Avedissian, Christina" sort="Avedissian, Christina" uniqKey="Avedissian C" first="Christina" last="Avedissian">Christina Avedissian</name><affiliation><mods:affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name><affiliation><mods:affiliation>Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Janvin, Carmen C" sort="Janvin, Carmen C" uniqKey="Janvin C" first="Carmen C." last="Janvin">Carmen C. Janvin</name><affiliation><mods:affiliation>Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P." last="Larsen">Jan P. Larsen</name><affiliation><mods:affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Cummings, Jeffrey L" sort="Cummings, Jeffrey L" uniqKey="Cummings J" first="Jeffrey L." last="Cummings">Jeffrey L. Cummings</name><affiliation><mods:affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name><affiliation><mods:affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-04-30">2010-04-30</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="687">687</biblScope><biblScope unit="page" to="695">695</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">1824A5CBC15FB75455AF4933654F2D3BEB83392C</idno><idno type="DOI">10.1002/mds.22799</idno><idno type="ArticleID">MDS22799</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson disease dementia (PDD)</term><term>caudate atrophy</term><term>hippocampal atrophy</term><term>mild cognitive impairment (MCI)</term><term>ventricular enlargement</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) has been associated with mild cognitive impairment (PDMCI) and with dementia (PDD). Using radial distance mapping, we studied the 3D structural and volumetric differences between the hippocampi, caudates, and lateral ventricles in 20 cognitively normal elderly (NC), 12 cognitively normal PD (PDND), 8 PDMCI, and 15 PDD subjects and examined the associations between these structures and Unified Parkinson's Disease Rating Scale (UPDRS) Part III:motor subscale and Mini‐Mental State Examination (MMSE) performance. There were no hippocampal differences between the groups. 3D caudate statistical maps demonstrated significant left medial and lateral and right medial atrophy in the PDD vs. NC, and right medial and lateral caudate atrophy in PDD vs. PDND. PDMCI showed trend‐level significant left lateral caudate atrophy vs. NC. Both left and right ventricles were significantly larger in PDD relative to the NC and PDND with posterior (body/occipital horn) predominance. The magnitude of regionally significant between‐group differences in radial distance ranged between 20–30% for caudate and 5–20% for ventricles. UPDRS Part III:motor subscale score correlated with ventricular enlargement. MMSE showed significant correlation with expansion of the posterior lateral ventricles and trend‐level significant correlation with caudate head atrophy. Cognitive decline in PD is associated with anterior caudate atrophy and ventricular enlargement. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Liana G. Apostolova MD</name><affiliations><json:string>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</json:string><json:string>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</json:string></affiliations></json:item><json:item><name>Mona Beyer MD, PhD</name><affiliations><json:string>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Amity E. Green BS</name><affiliations><json:string>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</json:string><json:string>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</json:string></affiliations></json:item><json:item><name>Kristy S. Hwang BS</name><affiliations><json:string>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</json:string><json:string>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</json:string></affiliations></json:item><json:item><name>Jonathan H. Morra PhD</name><affiliations><json:string>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</json:string><json:string>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</json:string></affiliations></json:item><json:item><name>Yi‐Yu Chou MS</name><affiliations><json:string>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</json:string><json:string>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</json:string></affiliations></json:item><json:item><name>Christina Avedissian BS</name><affiliations><json:string>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</json:string><json:string>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</json:string></affiliations></json:item><json:item><name>Dag Aarsland MD, PhD</name><affiliations><json:string>Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Carmen C. Janvin PhD</name><affiliations><json:string>Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Jan P. Larsen MD, PhD</name><affiliations><json:string>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Jeffrey L. Cummings MD</name><affiliations><json:string>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</json:string><json:string>Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, California, USA</json:string></affiliations></json:item><json:item><name>Paul M. Thompson PhD</name><affiliations><json:string>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</json:string><json:string>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson disease dementia (PDD)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mild cognitive impairment (MCI)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hippocampal atrophy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>caudate atrophy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>ventricular enlargement</value></json:item></subject><articleId><json:string>MDS22799</json:string></articleId><language><json:string>eng</json:string></language><abstract>Parkinson's disease (PD) has been associated with mild cognitive impairment (PDMCI) and with dementia (PDD). Using radial distance mapping, we studied the 3D structural and volumetric differences between the hippocampi, caudates, and lateral ventricles in 20 cognitively normal elderly (NC), 12 cognitively normal PD (PDND), 8 PDMCI, and 15 PDD subjects and examined the associations between these structures and Unified Parkinson's Disease Rating Scale (UPDRS) Part III:motor subscale and Mini‐Mental State Examination (MMSE) performance. There were no hippocampal differences between the groups. 3D caudate statistical maps demonstrated significant left medial and lateral and right medial atrophy in the PDD vs. NC, and right medial and lateral caudate atrophy in PDD vs. PDND. PDMCI showed trend‐level significant left lateral caudate atrophy vs. NC. Both left and right ventricles were significantly larger in PDD relative to the NC and PDND with posterior (body/occipital horn) predominance. The magnitude of regionally significant between‐group differences in radial distance ranged between 20–30% for caudate and 5–20% for ventricles. UPDRS Part III:motor subscale score correlated with ventricular enlargement. MMSE showed significant correlation with expansion of the posterior lateral ventricles and trend‐level significant correlation with caudate head atrophy. Cognitive decline in PD is associated with anterior caudate atrophy and ventricular enlargement. © 2010 Movement Disorder Society</abstract><qualityIndicators><score>7.093</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1503</abstractCharCount><pdfWordCount>4597</pdfWordCount><pdfCharCount>30228</pdfCharCount><pdfPageCount>9</pdfPageCount><abstractWordCount>208</abstractWordCount></qualityIndicators><title>Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia</title><genre><json:string>article</json:string></genre><host><volume>25</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>2</total><last>695</last><first>687</first></pages><issn><json:string>0885-3185</json:string></issn><issue>6</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1002/mds.22799</json:string></doi><id>1824A5CBC15FB75455AF4933654F2D3BEB83392C</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/1824A5CBC15FB75455AF4933654F2D3BEB83392C/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/1824A5CBC15FB75455AF4933654F2D3BEB83392C/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/1824A5CBC15FB75455AF4933654F2D3BEB83392C/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2010</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: None reported</note><note>NIA - No. K23 AG026803;</note><note>Turken Foundation</note><note>NIA - No. AG16570;</note><note>NIBIB - No. EB01651;</note><note>NLM - No. LM05639;</note><note>NCRR - No. RR019771;</note><note>NIMH - No. R01 MH071940;</note><note>NCRR - No. P41RR013642;</note><note>NIH - No. U54 RR021813;</note><note>Western Norway Regional Health Authority</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia</title><author><persName><forename type="first">Liana G.</forename><surname>Apostolova</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Mary S. Easton Center Alzheimer's Disease Center, 10911 Weyburn Ave, 2nd floor, Los Angeles, CA 90095</p></note><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</affiliation><affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</affiliation></author><author><persName><forename type="first">Mona</forename><surname>Beyer</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Amity E.</forename><surname>Green</surname></persName><roleName type="degree">BS</roleName><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</affiliation><affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</affiliation></author><author><persName><forename type="first">Kristy S.</forename><surname>Hwang</surname></persName><roleName type="degree">BS</roleName><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</affiliation><affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</affiliation></author><author><persName><forename type="first">Jonathan H.</forename><surname>Morra</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</affiliation><affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</affiliation></author><author><persName><forename type="first">Yi‐Yu</forename><surname>Chou</surname></persName><roleName type="degree">MS</roleName><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</affiliation><affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</affiliation></author><author><persName><forename type="first">Christina</forename><surname>Avedissian</surname></persName><roleName type="degree">BS</roleName><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</affiliation><affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</affiliation></author><author><persName><forename type="first">Dag</forename><surname>Aarsland</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Carmen C.</forename><surname>Janvin</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Jan P.</forename><surname>Larsen</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Jeffrey L.</forename><surname>Cummings</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</affiliation><affiliation>Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, California, USA</affiliation></author><author><persName><forename type="first">Paul M.</forename><surname>Thompson</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</affiliation><affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-04-30"></date><biblScope unit="volume">25</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="687">687</biblScope><biblScope unit="page" to="695">695</biblScope></imprint></monogr><idno type="istex">1824A5CBC15FB75455AF4933654F2D3BEB83392C</idno><idno type="DOI">10.1002/mds.22799</idno><idno type="ArticleID">MDS22799</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Parkinson's disease (PD) has been associated with mild cognitive impairment (PDMCI) and with dementia (PDD). Using radial distance mapping, we studied the 3D structural and volumetric differences between the hippocampi, caudates, and lateral ventricles in 20 cognitively normal elderly (NC), 12 cognitively normal PD (PDND), 8 PDMCI, and 15 PDD subjects and examined the associations between these structures and Unified Parkinson's Disease Rating Scale (UPDRS) Part III:motor subscale and Mini‐Mental State Examination (MMSE) performance. There were no hippocampal differences between the groups. 3D caudate statistical maps demonstrated significant left medial and lateral and right medial atrophy in the PDD vs. NC, and right medial and lateral caudate atrophy in PDD vs. PDND. PDMCI showed trend‐level significant left lateral caudate atrophy vs. NC. Both left and right ventricles were significantly larger in PDD relative to the NC and PDND with posterior (body/occipital horn) predominance. The magnitude of regionally significant between‐group differences in radial distance ranged between 20–30% for caudate and 5–20% for ventricles. UPDRS Part III:motor subscale score correlated with ventricular enlargement. MMSE showed significant correlation with expansion of the posterior lateral ventricles and trend‐level significant correlation with caudate head atrophy. Cognitive decline in PD is associated with anterior caudate atrophy and ventricular enlargement. © 2010 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson disease dementia (PDD)</term></item><item><term>mild cognitive impairment (MCI)</term></item><item><term>hippocampal atrophy</term></item><item><term>caudate atrophy</term></item><item><term>ventricular enlargement</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-02-19">Received</change><change when="2009-08-21">Registration</change><change when="2010-04-30">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/1824A5CBC15FB75455AF4933654F2D3BEB83392C/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="60"><doi origin="wiley" registered="yes">10.1002/mds.v25:6</doi><numberingGroup><numbering type="journalVolume" number="25">25</numbering><numbering type="journalIssue">6</numbering></numberingGroup><coverDate startDate="2010-04-30">30 April 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="40" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22799</doi><idGroup><id type="unit" value="MDS22799"></id></idGroup><countGroup><count type="pageTotal" number="2"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2010 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2009-02-19"></event><event type="manuscriptRevised" date="2009-06-22"></event><event type="manuscriptAccepted" date="2009-08-21"></event><event type="firstOnline" date="2010-04-01"></event><event type="publishedOnlineFinalForm" date="2010-04-26"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2010-04-01"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.5.2 mode:FullText" date="2011-08-12"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">687</numbering><numbering type="pageLast">695</numbering></numberingGroup><correspondenceTo>Mary S. Easton Center Alzheimer's Disease Center, 10911 Weyburn Ave, 2nd floor, Los Angeles, CA 90095</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22799.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="4"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="38"></count><count type="wordTotal" number="5296"></count></countGroup><titleGroup><title type="main" xml:lang="en">Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia<link href="#fn1"></link></title><title type="short" xml:lang="en">Changes in PD With and Without Dementia</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>Liana G.</givenNames><familyName>Apostolova</familyName><degrees>MD</degrees></personName><contactDetails><email>lapostolova@mednet.ucla.edu</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Mona</givenNames><familyName>Beyer</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Amity E.</givenNames><familyName>Green</familyName><degrees>BS</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Kristy S.</givenNames><familyName>Hwang</familyName><degrees>BS</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Jonathan H.</givenNames><familyName>Morra</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Yi‐Yu</givenNames><familyName>Chou</familyName><degrees>MS</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Christina</givenNames><familyName>Avedissian</familyName><degrees>BS</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Dag</givenNames><familyName>Aarsland</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Carmen C.</givenNames><familyName>Janvin</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Jan P.</givenNames><familyName>Larsen</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af1 #af6"><personName><givenNames>Jeffrey L.</givenNames><familyName>Cummings</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Paul M.</givenNames><familyName>Thompson</familyName><degrees>PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="NO" type="organization"><unparsedAffiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="NO" type="organization"><unparsedAffiliation>Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="NO" type="organization"><unparsedAffiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="US" type="organization"><unparsedAffiliation>Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, California, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson disease dementia (PDD)</keyword><keyword xml:id="kwd2">mild cognitive impairment (MCI)</keyword><keyword xml:id="kwd3">hippocampal atrophy</keyword><keyword xml:id="kwd4">caudate atrophy</keyword><keyword xml:id="kwd5">ventricular enlargement</keyword></keywordGroup><fundingInfo><fundingAgency>NIA</fundingAgency><fundingNumber>K23 AG026803</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Turken Foundation</fundingAgency></fundingInfo><fundingInfo><fundingAgency>NIA</fundingAgency><fundingNumber>AG16570</fundingNumber></fundingInfo><fundingInfo><fundingAgency>NIBIB</fundingAgency><fundingNumber>EB01651</fundingNumber></fundingInfo><fundingInfo><fundingAgency>NLM</fundingAgency><fundingNumber>LM05639</fundingNumber></fundingInfo><fundingInfo><fundingAgency>NCRR</fundingAgency><fundingNumber>RR019771</fundingNumber></fundingInfo><fundingInfo><fundingAgency>NIMH</fundingAgency><fundingNumber>R01 MH071940</fundingNumber></fundingInfo><fundingInfo><fundingAgency>NCRR</fundingAgency><fundingNumber>P41RR013642</fundingNumber></fundingInfo><fundingInfo><fundingAgency>NIH</fundingAgency><fundingNumber>U54 RR021813</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Western Norway Regional Health Authority</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Parkinson's disease (PD) has been associated with mild cognitive impairment (PDMCI) and with dementia (PDD). Using radial distance mapping, we studied the 3D structural and volumetric differences between the hippocampi, caudates, and lateral ventricles in 20 cognitively normal elderly (NC), 12 cognitively normal PD (PDND), 8 PDMCI, and 15 PDD subjects and examined the associations between these structures and Unified Parkinson's Disease Rating Scale (UPDRS) Part III:motor subscale and Mini‐Mental State Examination (MMSE) performance. There were no hippocampal differences between the groups. 3D caudate statistical maps demonstrated significant left medial and lateral and right medial atrophy in the PDD vs. NC, and right medial and lateral caudate atrophy in PDD vs. PDND. PDMCI showed trend‐level significant left lateral caudate atrophy vs. NC. Both left and right ventricles were significantly larger in PDD relative to the NC and PDND with posterior (body/occipital horn) predominance. The magnitude of regionally significant between‐group differences in radial distance ranged between 20–30% for caudate and 5–20% for ventricles. UPDRS Part III:motor subscale score correlated with ventricular enlargement. MMSE showed significant correlation with expansion of the posterior lateral ventricles and trend‐level significant correlation with caudate head atrophy. Cognitive decline in PD is associated with anterior caudate atrophy and ventricular enlargement. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: None reported</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Changes in PD With and Without Dementia</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia</title></titleInfo><name type="personal"><namePart type="given">Liana G.</namePart><namePart type="family">Apostolova</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</affiliation><affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</affiliation><description>Correspondence: Mary S. Easton Center Alzheimer's Disease Center, 10911 Weyburn Ave, 2nd floor, Los Angeles, CA 90095</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mona</namePart><namePart type="family">Beyer</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Amity E.</namePart><namePart type="family">Green</namePart><namePart type="termsOfAddress">BS</namePart><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</affiliation><affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kristy S.</namePart><namePart type="family">Hwang</namePart><namePart type="termsOfAddress">BS</namePart><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</affiliation><affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jonathan H.</namePart><namePart type="family">Morra</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</affiliation><affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yi‐Yu</namePart><namePart type="family">Chou</namePart><namePart type="termsOfAddress">MS</namePart><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</affiliation><affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christina</namePart><namePart type="family">Avedissian</namePart><namePart type="termsOfAddress">BS</namePart><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</affiliation><affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dag</namePart><namePart type="family">Aarsland</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carmen C.</namePart><namePart type="family">Janvin</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan P.</namePart><namePart type="family">Larsen</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jeffrey L.</namePart><namePart type="family">Cummings</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</affiliation><affiliation>Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paul M.</namePart><namePart type="family">Thompson</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, California, USA</affiliation><affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-04-30</dateIssued><dateCaptured encoding="w3cdtf">2009-02-19</dateCaptured><dateValid encoding="w3cdtf">2009-08-21</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">4</extent><extent unit="tables">1</extent><extent unit="references">38</extent><extent unit="words">5296</extent></physicalDescription><abstract lang="en">Parkinson's disease (PD) has been associated with mild cognitive impairment (PDMCI) and with dementia (PDD). Using radial distance mapping, we studied the 3D structural and volumetric differences between the hippocampi, caudates, and lateral ventricles in 20 cognitively normal elderly (NC), 12 cognitively normal PD (PDND), 8 PDMCI, and 15 PDD subjects and examined the associations between these structures and Unified Parkinson's Disease Rating Scale (UPDRS) Part III:motor subscale and Mini‐Mental State Examination (MMSE) performance. There were no hippocampal differences between the groups. 3D caudate statistical maps demonstrated significant left medial and lateral and right medial atrophy in the PDD vs. NC, and right medial and lateral caudate atrophy in PDD vs. PDND. PDMCI showed trend‐level significant left lateral caudate atrophy vs. NC. Both left and right ventricles were significantly larger in PDD relative to the NC and PDND with posterior (body/occipital horn) predominance. The magnitude of regionally significant between‐group differences in radial distance ranged between 20–30% for caudate and 5–20% for ventricles. UPDRS Part III:motor subscale score correlated with ventricular enlargement. MMSE showed significant correlation with expansion of the posterior lateral ventricles and trend‐level significant correlation with caudate head atrophy. Cognitive decline in PD is associated with anterior caudate atrophy and ventricular enlargement. © 2010 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported</note><note type="funding">NIA - No. K23 AG026803; </note><note type="funding">Turken Foundation</note><note type="funding">NIA - No. AG16570; </note><note type="funding">NIBIB - No. EB01651; </note><note type="funding">NLM - No. LM05639; </note><note type="funding">NCRR - No. RR019771; </note><note type="funding">NIMH - No. R01 MH071940; </note><note type="funding">NCRR - No. P41RR013642; </note><note type="funding">NIH - No. U54 RR021813; </note><note type="funding">Western Norway Regional Health Authority</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson disease dementia (PDD)</topic><topic>mild cognitive impairment (MCI)</topic><topic>hippocampal atrophy</topic><topic>caudate atrophy</topic><topic>ventricular enlargement</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>687</start><end>695</end><total>2</total></extent></part></relatedItem><identifier type="istex">1824A5CBC15FB75455AF4933654F2D3BEB83392C</identifier><identifier type="DOI">10.1002/mds.22799</identifier><identifier type="ArticleID">MDS22799</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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